{"id":1953,"date":"2017-03-31T16:53:47","date_gmt":"2017-03-31T16:53:47","guid":{"rendered":"http:\/\/www.papsonline.org\/?page_id=1953\/"},"modified":"2017-04-01T14:51:26","modified_gmt":"2017-04-01T14:51:26","slug":"papsummer","status":"publish","type":"page","link":"https:\/\/www.paps.pt\/pt-pt\/papsummer\/","title":{"rendered":"PAPSummer"},"content":{"rendered":"<p><div  class=\"fusion-fullwidth fullwidth-box fusion-parallax-none nonhundred-percent-fullwidth fusion-equal-height-columns\"  style='background-color: #00bcd4;background-image: url(\"http:\/\/www.paps.pt\/wp-content\/uploads\/2017\/02\/paps-lightsbannerx2.jpg\");background-position: center center;background-repeat: no-repeat;padding-top:20px;padding-right:0px;padding-left:0px;border-top-width:0px;border-bottom-width:0px;border-color:#eae9e9;border-top-style:solid;border-bottom-style:solid;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-attachment:none;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1  fusion-one-full fusion-column-first fusion-column-last 1_1\"  style='margin-top:0px;margin-bottom:15px;'>\n\t\t\t<div class=\"fusion-column-wrapper\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\">\n\t\t\t\t<div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-title title fusion-sep-none fusion-title-size-one\" style=\"margin-top:0px;margin-bottom:0px;\"><h1 class=\"title-heading-left\"><h1 class=\"white\">PAPSummer<\/h1><\/h1><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t<\/div>\n\t\t<\/div><\/div><\/div><div  class=\"fusion-fullwidth fullwidth-box nonhundred-percent-fullwidth fusion-equal-height-columns\"  style='background-color: #ebedf0;background-position: left top;background-repeat: no-repeat;padding-top:20px;padding-right:0px;padding-bottom:20px;padding-left:0px;border-top-width:0px;border-bottom-width:0px;border-color:#eae9e9;border-top-style:solid;border-bottom-style:solid;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1  fusion-one-full fusion-column-first fusion-column-last 1_1\"  style='margin-top:0px;margin-bottom:20px;'>\n\t\t\t<div class=\"fusion-column-wrapper\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\">\n\t\t\t\t<div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><h3>Sobre o PAPSummer<\/h3>\n<h4><strong>O programa PAPSummer foi iniciado em 2015 com o objetivo de possibilitar a estudantes portugueses terem a oportunidade de estagiar, por um m\u00eas, numa empresa, universidade ou centro de investiga\u00e7\u00e3o nos Estados Unidos ou Canad\u00e1. Os est\u00e1gios s\u00e3o na sua maioria supervisionados por um membro PAPS. Mais informa\u00e7\u00f5es\u00a0<a href=\"http:\/\/www.papsummer.paps.pt\/\" target=\"_blank\">aqui<\/a>.<\/strong><\/h4>\n<\/div><\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t<\/div>\n\t\t<\/div><\/div><\/div><div  class=\"fusion-fullwidth fullwidth-box hundred-percent-fullwidth\"  style='background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:30px;padding-bottom:0px;padding-left:30px;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1  fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height 1_1\"  style='margin-top:0px;margin-bottom:0px;'>\n\t\t\t<div class=\"fusion-column-wrapper\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\">\n\t\t\t\t<div class=\"fusion-section-separator section-separator\" style=\"border-bottom:1px solid #384666;margin-left:-30px;margin-right:-30px;\"><div class=\"divider-candy-arrow bottom\" style=\"top:0px;border-top-color: #384666;\"><\/div><div class=\"divider-candy bottom\" style=\"bottom:-21px;border-bottom:1px solid #384666;border-left:1px solid #384666;\"><\/div><\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t<\/div>\n\t\t<\/div><\/div><\/div><div  class=\"fusion-fullwidth fullwidth-box nonhundred-percent-fullwidth\"  style='background-color: rgba(255,255,255,0);background-position: left top;background-repeat: no-repeat;padding-top:40px;padding-right:0px;padding-bottom:20px;padding-left:0px;border-top-width:0px;border-bottom-width:0px;border-color:#eae9e9;border-top-style:solid;border-bottom-style:solid;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_3_4  fusion-three-fourth fusion-column-first 3_4\"  style='margin-top:0px;margin-bottom:20px;width:74%; margin-right: 4%;'>\n\t\t\t<div class=\"fusion-column-wrapper\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\">\n\t\t\t\t<div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep sep-none\" style=\"margin-left: auto;margin-right: auto;margin-top:20px;margin-bottom:0px;\"><\/div><div class=\"fusion-tabs fusion-tabs-1 classic horizontal-tabs\"><style type=\"text\/css\">.fusion-tabs.fusion-tabs-1 .nav-tabs li a{border-top-color:#ebeaea;background-color:#ebeaea;}.fusion-tabs.fusion-tabs-1 .nav-tabs{background-color:#ffffff;}.fusion-tabs.fusion-tabs-1 .nav-tabs li.active a,.fusion-tabs.fusion-tabs-1 .nav-tabs li.active a:hover,.fusion-tabs.fusion-tabs-1 .nav-tabs li.active a:focus{border-right-color:#ffffff;}.fusion-tabs.fusion-tabs-1 .nav-tabs li.active a,.fusion-tabs.fusion-tabs-1 .nav-tabs li.active a:hover,.fusion-tabs.fusion-tabs-1 .nav-tabs li.active a:focus{background-color:#ffffff;}.fusion-tabs.fusion-tabs-1 .nav-tabs li a:hover{background-color:#ffffff;border-top-color:#ffffff;}.fusion-tabs.fusion-tabs-1 .tab-pane{background-color:#ffffff;}.fusion-tabs.fusion-tabs-1 .nav,.fusion-tabs.fusion-tabs-1 .nav-tabs,.fusion-tabs.fusion-tabs-1 .tab-content .tab-pane{border-color:#ebeaea;}<\/style><div class=\"nav\"><ul class=\"nav-tabs nav-justified\"><li class=\"active\"><a class=\"tab-link\" data-toggle=\"tab\" id=\"fusion-tab-2015\" href=\"#tab-97a7d2910d15f1bf425\"><h4 class=\"fusion-tab-heading\">2015<\/h4><\/a><\/li><li><a class=\"tab-link\" data-toggle=\"tab\" id=\"fusion-tab-2016\" href=\"#tab-5f45c3600825aed2a5c\"><h4 class=\"fusion-tab-heading\">2016<\/h4><\/a><\/li><li><a class=\"tab-link\" data-toggle=\"tab\" id=\"fusion-tab-2017\" href=\"#tab-d50719bfcae37bebbfb\"><h4 class=\"fusion-tab-heading\">2017<\/h4><\/a><\/li><\/ul><\/div><div class=\"tab-content\"><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs nav-justified\"><li class=\"active\"><a class=\"tab-link\" data-toggle=\"tab\" id=\"fusion-tab-2015\" href=\"#tab-97a7d2910d15f1bf425\"><h4 class=\"fusion-tab-heading\">2015<\/h4><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade in active\" id=\"tab-97a7d2910d15f1bf425\">\n<p>A primeira edi\u00e7\u00e3o do programa, o PAPSummer 2015, recebeu mais de 500 candidaturas de alunos portugueses com variados percursos acad\u00e9micos e de diversas \u00e1reas geogr\u00e1ficas. Foram selecionados oito alunos a quem foi atribu\u00edda uma bolsa PAPSummer para desenvolver projetos de est\u00e1gio em prestigiadas universidades, institui\u00e7\u00f5es e empresas norte-americanas tais como Harvard Medical School, Space Telescope Science Institute (NASA), Consulado Geral de Portugal em Nova Iorque e a empresa de consultadoria Axis Advisors.<\/p>\n<div class=\"accordian fusion-accordian\"><div class=\"panel-group\" id=\"accordion-1953-1\"><div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#978efe90c09eca7c5\" href=\"#978efe90c09eca7c5\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Experimental evolution of genetic instability during a yeast model of cancer progression.<\/div><\/a><\/h4><\/div><div id=\"978efe90c09eca7c5\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cExperimental evolution of genetic instability during a yeast model of cancer progression\u201d<br \/>\n<strong>Field:<\/strong> Biology, biochemistry, evolution<br \/>\n<strong>City:<\/strong> Boston, MA<br \/>\n<strong>Supervisor:<\/strong> Miguel Costa Coelho<br \/>\n<strong>Affiliation:<\/strong> FAS Center for Systems Biology, Harvard University<\/p>\n<p>Life depends on the faithful transmission of genetic information. During cancer progression, the selection for successive mutations favors the evolution of genetic instability (GI), characterized by increased mutation rates. However, it is not clear how GI \u00ad defects in DNA repair\/replication, chromosome rearrangements or loss \u00ad arises and evolves. By placing yeast cells under selective pressure to inactivate growth suppression, similarly to what occurs in tumors, we have evolved and quantified GI in three genetic architectures: 1) haploids, 2) diploids heterozygous for the growth suppressor gene, and 3) most similar to cancer \u2013 diploids homozygous for the growth suppressor gene.<\/p>\n<p>One mutation is sufficient to cause GI in the evolved clones, but in some clones &gt;1 mutations contribute to GI. Using mutation segregation analysis and whole genome sequencing we identified both loss\u00adof\u00adfunction and putative gain\u00ad of\u00adfunction mutations, also in essential genes, that drive GI. There were 3 prevalent classes of mutations: 1) DNA repair, 2) Protein stability and 3) Mitochondrial genes. To test whether these mutations were causative, we re\u00ad engineered them back into the ancestor, time traveling to test the origin of instability. For a subset of genes in each class, the re\u00adengineered mutation increased GI, proving causality. Conversely, replacing the mutated allele with the wild\u00adtype copy in the evolved clone restored genetic stability. The majority of the mutations we discovered lie in genes not previously related to GI in yeast, and half are related to human cancer genes.<\/p>\n<p>In contrast to classic screens where gene deletions were used, to unbiasedly select for increased mutation rate allows evolution to tell us how GI arises. We will proceed to functionally test how protein stability or mitochondrial disfunction affect GI, and analyze the mutational signatures of the evolved GI, focusing on conserved genes to bridge our work with human cancer.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#da03d86724724172e\" href=\"#da03d86724724172e\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Cloud-based NGS Data Processing<\/div><\/a><\/h4><\/div><div id=\"da03d86724724172e\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cCloud-based NGS Data Processing\u201d<br \/>\n<strong>Field:<\/strong> Computational Genomics<br \/>\n<strong>City:<\/strong> Long Island, NY<br \/>\n<strong>Supervisor:<\/strong> Jonas Almeida<br \/>\n<strong>Affiliation:<\/strong> Stony Brook University<\/p>\n<p>O desenvolvimento de NGS (next generation sequencing), transformou a sequenciac\u0327a\u0303o geno\u0301mica num me\u0301todo laboratorial rotineiro. Desta forma o desafio passa do processamento da amostra para o processamento da grande abundancia de dados que sa\u0303o assim gerados. Este esta\u0301gio esta\u0301 inserido num projecto de geno\u0301mica da evoluc\u0327a\u0303o da resiste\u0302ncia a antibio\u0301ticos em Streptococcus pneumoniae, e tem como objectivo familiarizar o participante com a execuc\u0327a\u0303o de me\u0301todos computacionais de NGS na nuvem (por exemplo usando dnaNexus) e na representac\u0327a\u0303o dos resultados da ana\u0301lise na forma de uma aplicac\u0327a\u0303o em rede.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#7e18ac1841aafccc1\" href=\"#7e18ac1841aafccc1\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">When Myonuclear Positioning Goes Wrong<\/div><\/a><\/h4><\/div><div id=\"7e18ac1841aafccc1\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cWhen Myonuclear Positioning Goes Wrong\u201d<br \/>\n<strong>Field:<\/strong> Developmental biology<br \/>\n<strong>City:<\/strong> New York, NY<br \/>\n<strong>Supervisor:<\/strong> Mafalda Azevedo<br \/>\n<strong>Affiliation:<\/strong> Memorial Sloan-Kettering Cancer Center<\/p>\n<p>Mammalian skeletal muscle is composed of bundles of multinucleated myofibers. Myonuclei reside above the sarcomere at the periphery of the muscle fiber and are positioned to maximize their internuclear distance. Mispositioned myonuclei are a hallmark of many muscle disorders, such as Centronuclear Myopathies and Emery-Dreifuss Muscular Dystrophy, and have been used diagnostically for decades.<\/p>\n<p>Nevertheless, the mechanisms driving myonuclear positioning remain unclear.<\/p>\n<p>To understand the mechanisms involved in myonuclear positioning, you will use Drosophila melanogaster (fruit fly) as a model organism. Drosophila serves as a simple and rapid system to investigate the basic mechanisms of myonuclear positioning and its effects on muscle function\/physiology. Data from our lab indicate that there is a striking correlation between aberrantly placed and clumped nuclei and a decrease in muscle function. Given the strong conservation of genes and mechanisms between the fruit fly and mammals, aberrant myonuclear positioning could contribute to the muscle deficits associated with muscle disease. Taking advantage of this model organism we will be assessing myonuclear positioning in two different stages of the Drosophila development: the embryonic and the larval stages.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#689ef9669cbdc4f8b\" href=\"#689ef9669cbdc4f8b\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Empirical Verification of the S I, Fe I, and Ni II Oscillator Strengths in the HST\/STIS bandpass<\/div><\/a><\/h4><\/div><div id=\"689ef9669cbdc4f8b\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<strong>Title:<\/strong> \u201cEmpirical Verification of the S I, Fe I, and Ni II Oscillator Strengths in the HST\/STIS bandpass\u201d<br \/>\n<strong>Field:<\/strong> Astronomy, astrophysics<br \/>\n<strong>City:<\/strong> Baltimore, MD<br \/>\n<strong>Supervisor:<\/strong> Cristina Oliveira<br \/>\n<strong>Affiliation:<\/strong> Space Telescope Science Institute<\/p>\n<p>The measurement and analysis of metal absorption lines in the spectra of distant stars and galaxies provides the basis for much of our understanding of the content, physical conditions, and evolution of the interstellar medium of galaxies, the circumgalactic medium of high redshift systems, chemical feedback in galaxies, how black holes accrete matter and grow through cosmic time, how did the universe become ionized, to name just a few topics. Critical to such absorption line spectroscopic measurements are the oscillator strengths, f-values, of the different atomic transitions for each element. The project of the PAPS Summer student will be to use the data and measurements already performed for S I, Fe I, and Ni II to determine updated oscillator strengths for some transitions which were found to have incorrect oscillator strengths during work performed recently. The student will start by evaluating all absorption line measurements already performed using the spectra of four stars to determine exactly which transitions might have incorrect f-values. The student will then do a literature seach to determine if any new theoretical or laboratory measurements are available for the questionable f-values. He\/She will then use robust f-values to anchor the absorption line measurements and determine updated f-values, including uncertainties.<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#878cc363163b43000\" href=\"#878cc363163b43000\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Genetic Modifiers of CAG Repeat Instability in Huntington\u2019s Disease<\/div><\/a><\/h4><\/div><div id=\"878cc363163b43000\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<strong>Title:<\/strong> \u201cGenetic Modifiers of CAG Repeat Instability in Huntington\u2019s Disease\u201d<br \/>\n<strong>Field:<\/strong> Neurogenetics, molecular biology<br \/>\n<strong>City:<\/strong> Boston, MA<br \/>\n<strong>Supervisor:<\/strong> Ricardo Mouro Pinto<br \/>\n<strong>Affiliation:<\/strong> Massachusetts General Hospital, Harvard Medical School<\/p>\n<p>The project will initially involve molecular biology and cloning techniques to generate constructs co-expressing Cas9 and sgRNAs for the 4 MMR genes (Msh2, Msh3, Mlh1 and Mlh3) which have been previously confirmed as enhancers of somatic CAG instability in our HD knockin mice. The ability to efficiently edit these target genes will be subsequently investigated by transfection into mouse fibroblast cell lines followed by T7 endonuclease 1 assays. Knockout efficacy will also be assessed by target gene expression analysis by qRT-PCR and Western Blotting. If time allows, these experiments will be extended to novel candidate genetic modifiers.<\/p>\n<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#a4bf9697bd98b5050\" href=\"#a4bf9697bd98b5050\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Communication and Public Diplomacy<\/div><\/a><\/h4><\/div><div id=\"a4bf9697bd98b5050\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<strong>Title:<\/strong> \u201cCommunication and Public Diplomacy\u201d<br \/>\n<strong>Field:<\/strong> Graphic and editorial design, information technology<br \/>\n<strong>City:<\/strong> New York, NY<br \/>\n<strong>Supervisor:<\/strong> Manuela Bairos<br \/>\n<strong>Affiliation:<\/strong> General Consulate of Portugal in New York<\/p>\n<p>O Consulado-Geral em NY foi recentemente reativado e pretende desenvolver uma estrate\u0301gia de diplomacia pu\u0301blica visando modernizar e dinamizar a inter- ac\u0327a\u0303o com os seus utentes e com o pu\u0301blico em geral. O esta\u0301gio devera\u0301 incidir sobre a identificac\u0327a\u0303o e desenvolvimento do potencial de instrumentos disponi\u0301veis para atingir esse pu\u0301blico alvo (website, redes sociais, newsbriefs, revista, etc) e na realizac\u0327a\u0303o de um levantamento e contactos com parceiros em NY e em Portugal nas a\u0301reas de atuac\u0327a\u0303o do Consulado que possam apoiar a promoc\u0327a\u0303o de Portugal.<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-1\" data-target=\"#dedb7ee5f8bc5e797\" href=\"#dedb7ee5f8bc5e797\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Financial Planning, Wealth and Risk Management Planning<\/div><\/a><\/h4><\/div><div id=\"dedb7ee5f8bc5e797\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<strong>Title:<\/strong> \u201cFinancial Planning, Wealth and Risk Management Planning\u201d<br \/>\n<strong>Field:<\/strong> Investment management, financial planning<br \/>\n<strong>City:<\/strong> Providence, RI<br \/>\n<strong>Supervisor:<\/strong> Daniel da Ponte<br \/>\n<strong>Affiliation:<\/strong> Axis Advisors, LLC and Rhode Island Senate<\/p>\n<p>Axis Advisors, LLC\u00a0is a registered investment advisor with offices in\u00a0East Providence, RI\u00a0and\u00a0Westport, MA. As a\u00a0fee-only\u00a0independent wealth management and financial planning firm, we work alongside\u00a0our clients and are fiduciaries for their best interests. We work with individuals and families, businesses and non-profit organizations to develop and manage their financial, investment and retirement plans. We do not have or sell any proprietary products and our fee structure is transparent to our clients.\u00a0We\u2019ve built a reputation for taking an approach to investing and managing assets that is aligned with our clients goals and objectives. We believe that by helping our clients identify their goals and by providing them with objective advice, we can help make financial decisions based on a well thought out strategy.\u00a0Our holistic approach to wealth management, financial and insurance planning takes into account all of the aspects of a client&#8217;s life and how they are connected. We create a plan that is specific to them. The intern we receive from PAPSummer will be exposed to the business side of managing a firm on a day to day basis. Once they are provided an overview of the firm and resources, they will be asked to perform research and participate in client meetings. Specific areas of exposure will be investment management research, financial planning software modules and an opportunities to develop hypothetical investment programs and financial plans. Intern may be asked to perform minor clerical work that is directly related to managing client relationship and client management systems. Intern must sign a confidentiality agreement upon commencement of their internship.<\/div><\/div><\/div><\/div><\/div><\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs nav-justified\"><li><a class=\"tab-link\" data-toggle=\"tab\" id=\"fusion-tab-2016\" href=\"#tab-5f45c3600825aed2a5c\"><h4 class=\"fusion-tab-heading\">2016<\/h4><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade\" id=\"tab-5f45c3600825aed2a5c\">\n<p>A segunda edi\u00e7\u00e3o do programa, o PAPSummer 2016 foi, novamente, um \u00eaxito. Concorreram a este programa de est\u00e1gios aproximadamente 250 alunos portugueses com variados percursos acad\u00e9micos e de diversas \u00e1reas geogr\u00e1ficas. Foram atribu\u00eddas cinco bolsas PAPSummer a cinco alunos que desenvolveram projectos de est\u00e1gio nas \u00e1reas de cinema, biologia\/medicina e astrof\u00edsica, em diversas institui\u00e7\u00f5es de prest\u00edgio nos Estados Unidos.<\/p>\n<div class=\"accordian fusion-accordian\"><div class=\"panel-group\" id=\"accordion-1953-2\">\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-2\" data-target=\"#d94bf02a665461e9b\" href=\"#d94bf02a665461e9b\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Short movie: Vozes na N\u00e9voa<\/div><\/a><\/h4><\/div><div id=\"d94bf02a665461e9b\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<strong>Title:<\/strong> \u201cShort movie: Vozes na N\u00e9voa\u201d<br \/>\n<strong>Field:<\/strong> Cinema<br \/>\n<strong>City:<\/strong> New York, NY and Bedford, MA<br \/>\n<strong>Supervisor:<\/strong> Pedro Marnoto Pereira<br \/>\n<strong>Affiliation:<\/strong> Park Bench Pictures<\/p>\n<p><span style=\"font-weight: 400;\">O projeto \u201cVozes da N\u00e9voa\u201d pretende fazer uma explora\u00e7\u00e3o da pesca do bacalhau nos bancos da Terra Nova pelos portugueses, assim como a sua rela\u00e7\u00e3o com a emigra\u00e7\u00e3o lusitana para os EUA em meados do s\u00e9culo XX. Para isso, realizer-se-\u00e3o entrevistas com antigos bacalhoeiros portugueses residentes em New Bedford, com o objectivo de completar uma curta-metragem documental.<\/span><\/p>\n<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-2\" data-target=\"#25836ad2d6f237c34\" href=\"#25836ad2d6f237c34\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Metabolic Reprogramming in the Offspring of Insulin Resistant Parents<\/div><\/a><\/h4><\/div><div id=\"25836ad2d6f237c34\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cMetabolic Reprogramming in the Offspring of Insulin Resistant Parents\u201d<br \/>\n<strong>Field:<\/strong> Biology, metabolism<br \/>\n<strong>City:<\/strong> Boston, MA<br \/>\n<strong>Supervisor:<\/strong> Dario F. de Jesus<br \/>\n<strong>Affiliation:<\/strong> Joslin Diabetes Center, Harvard Medical School<\/p>\n<p><span style=\"font-weight: 400;\">The main goals of this internship at the Joslin Diabetes Center (JDC) are 1) to understand the impact of <\/span><i><span style=\"font-weight: 400;\">in utero <\/span><\/i><span style=\"font-weight: 400;\">insulin resistance on physiology in the adult offspring 2) to understand paternal-induced metabolic changes in the offspring of insulin resistant fathers.<br \/>\n<\/span><span style=\"font-weight: 400;\">Diabetes mellitus is a metabolic disease that is mainly characterized by an abnormal raise in plasma glucose concentration. The etiology of the disease is vast and the complications lead to morbidity. Type-1 diabetes (T1D), or insulin- dependent diabetes, is acute, progresses quickly and is characterized by a complete insulin deficiency due to the loss of pancreatic beta cells by various factors (e.g., virus, environmental). Type-2 diabetes (T2D), or non-insulin-dependent diabetes, which was reported to be restricted to adults and elderly individuals, is now also recognized in adolescents due to undetermined factors [1]. Diabetes mellitus is increasing worldwide and by 2030 is expected to affect 366 million people [2]. During 2012 the total estimated cost of diabetes care in USA was 220 billion euros and represented more than 20% of the total health care budget [3]. On the other hand, 12.4% of the Portuguese population lived with diabetes in 2009. This resulted in an estimated total annual cost of 1.3 billion euros, representing 11% of the Portuguese healthcare budget [4]. Despite the identification of more than 100 genes conferring risk of diabetes, only a small portion of the disease risk can be ascribed to the genes. As progression to T2D is largely due to insulin secretory dysfunction and significant beta-cell loss, further research in understanding the epigenetic modifications in offspring beta-cells of insulin resistant parents, will likely play an important role in determining how elevated levels of insulin and glucose itself, influences the expression of important genes in beta cell function and survival.<\/span><\/p>\n<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-2\" data-target=\"#cec911bc035c9fb08\" href=\"#cec911bc035c9fb08\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">CRISPR\/Cas9-based Therapeutics for Friedreich's ataxia<\/div><\/a><\/h4><\/div><div id=\"cec911bc035c9fb08\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cCRISPR\/Cas9-based Therapeutics for Friedreich&#8217;s ataxia\u201d<br \/>\n<strong>Field:<\/strong> Molecular biology<br \/>\n<strong>City:<\/strong> Boston, MA<br \/>\n<strong>Supervisor:<\/strong> Ricardo Mouro Pinto<br \/>\n<strong>Affiliation:<\/strong> MGH, Harvard Medical School<\/p>\n<p><span style=\"font-weight: 400;\">O laborato\u0301rio esta\u0301 inserido no Center for Human Genetic Research (Massachusetts General Hospital \/ Harvard Medical School) e tem como interesses de investigac\u0327a\u0303o os mecanismos gene\u0301ticos e moleculares causadores de doenc\u0327as neurodegenerativas como a Ataxia de Friedreich Ataxia (FA) e a doenc\u0327a de Huntington (HD).<br \/>\n<\/span><span style=\"font-weight: 400;\">FA e\u0301 uma doenc\u0327a gene\u0301tica rara causada por uma repetic\u0327a\u0303o de trinucleo\u0301tideos GAA que quando expandida resulta num silenciamento gene\u0301tico e consequente reduc\u0327a\u0303o nos ni\u0301veis de frataxin.<br \/>\n<\/span><span style=\"font-weight: 400;\">Em particular, o projeto deste esta\u0301gio envolve o uso de modelos celulares e te\u0301cnicas de engenharia geno\u0301mica com o objetivo de aliviar o silenciamento gene\u0301tico na origem de FA.<br \/>\n<\/span><span style=\"font-weight: 400;\">O Estagia\u0301rio vai ser treinado numa se\u0301rie de te\u0301cnicas laboratoriais de forma a conduzir experie\u0302ncias preliminares que visam desenvolver e validar reagentes capazes de ativar de forma especi\u0301fica a expressa\u0303o do gene frataxin. Tais te\u0301cnicas incluem elementos ba\u0301sicos de biologia molecular (extrac\u0327a\u0303o de DNA, PCR, quantificac\u0327a\u0303o de expressa\u0303o gene\u0301tica, gel eletroforese), cultura de ce\u0301lulas humanas, transfec\u0327o\u0303es, e CRISPR Cas9.<\/span><\/p>\n<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-2\" data-target=\"#86991790520c3a854\" href=\"#86991790520c3a854\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Testing clinically relevant matrices for Schwann cell transplantation following spinal cord injury<\/div><\/a><\/h4><\/div><div id=\"86991790520c3a854\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cTesting clinically relevant matrices for Schwann cell transplantation following spinal cord injury\u201d<br \/>\n<strong>Field:<\/strong> Regenerative medicine<br \/>\n<strong>City:<\/strong> Miami, FL<br \/>\n<strong>Supervisor:<\/strong> Susana Cerqueira<br \/>\n<strong>Affiliation:<\/strong> Miller School of Medicine, University of Miami<\/p>\n<p><span style=\"font-weight: 400;\">Cell therapy strategies to repair the injured spinal cord are promising new breakthroughs with the recent clinical trials in acute and chronic spinal cord injury (SCI) subjects [1]. Following an insult to the mammalian spinal cord, a series of complex responses follow that contribute to an aggravated expansion of the initial injury, and result in dramatic functional deficits [2]. The formation of fluid-filled cavities contributes, in part, to the regenerative failure and functional deficits that follow SCI. Cell transplantation strategies rely on reducing cavitation following damage, re-bridging the injured tissue and creating more favorable conditions for axonal regeneration. From the various cell types proposed to be used in SCI repair, Schwann cells (SCs) have been extensively studied and are currently undergoing safety and efficacy evaluation in clinical trials in the Miami Project to Cure Paralysis. SCs are the myelinating glia of the peripheral nervous system, and can be obtained from SCI patients, expanded in culture, and autologously transplanted into the lesioned spinal cord. These cells were found to be neuroprotective, reduce cavitation, promote axon regeneration and myelination, and modestly improve hindlimb movements in animal models [3, 4]. Nevertheless, one of the hurdles that may be limiting the therapeutic potential of SC implants, as well as other cell types, is the poor survival rate of the transplanted cells in the injury site [5]. Previous reports have shown that after a contusion injury in rats, there is about an 80% SC loss 3 weeks after transplantation due to necrosis and apoptosis [6, 7]. The traumatic nature of cell isolation procedures, the detachment from its extracellular matrix (ECM) before transplantation, and the injury environments are some factors that contribute to this significant cell death.<br \/>\n<\/span><span style=\"font-weight: 400;\">One possible approach to improve transplanted SC survival, therefore maximizing its therapeutic potential, is to implant them in ECM-derived substrates, such as an injectable matrix, instead of the culture media suspension approach. Most commercial ECM matrices, however, are tumor-derived and have undefined and variable growth-factor composition. For these reasons, they are not clinically applicable and it still remains of the utmost importance to identify clinically relevant injectable matrices for achieving greater survival and efficacy of cellular implants after SCI. <\/span><b>The goal of this project<\/b> <span style=\"font-weight: 400;\">is to evaluate the potential of ECM-derived matrices in supporting SC survival after injury, while fostering neuronal regeneration through the graft. It will be a project involving concepts and techniques from biomaterials and biomedical research, and envisioning future translational studies for clinical applications.<\/span><\/p>\n<\/div><\/div><\/div>\n<div class=\"fusion-panel panel-default\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\"><a data-toggle=\"collapse\" data-parent=\"#accordion-1953-2\" data-target=\"#2afd5578fdfeb7eeb\" href=\"#2afd5578fdfeb7eeb\"><div class=\"fusion-toggle-icon-wrapper\"><i class=\"fa-fusion-box\"><\/i><\/div><div class=\"fusion-toggle-heading\">Assessment of saturation effects in abundance measurements of extragalactic sight lines using nearby stars<\/div><\/a><\/h4><\/div><div id=\"2afd5578fdfeb7eeb\" class=\"panel-collapse collapse \"><div class=\"panel-body toggle-content\">\n<p><strong>Title:<\/strong> \u201cAssessment of saturation effects in abundance measurements of extragalactic sight lines using nearby stars\u201d<br \/>\n<strong>Field:<\/strong> Astrophysics<br \/>\n<strong>City:<\/strong> Baltimore, MD<br \/>\n<strong>Supervisor:<\/strong> Cristina Oliveira<br \/>\n<strong>Affiliation:<\/strong> Space Telescope Science Institute<\/p>\n<p><span style=\"font-weight: 400;\">Measurements of chemical abundances in local galaxies are different from measurements along single sight lines because light from all the stars in the galaxy is collected as if the galaxy was a single point source. These stars probe different portions of a galaxy, some with different chemical abundances and physical conditions, and can hide saturation effects. Spectra of local galaxies might also have low S\/N, which further compounds the problem. This project consists of assessing the saturation effects in abundance measurements of extragalactic sight lines by using nearby stars to measure abundances in each sightline individually as well as in the combined spectrum of all the stars, to simulate a galaxy spectrum. The measurements will use the apparent optical depth technique on echelle data obtained with the Space Telescope Imaging Spectrograph (STIS) onboard the Hubble Space Telescope (HST).<\/span><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div><\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs nav-justified\"><li><a class=\"tab-link\" data-toggle=\"tab\" id=\"fusion-tab-2017\" href=\"#tab-d50719bfcae37bebbfb\"><h4 class=\"fusion-tab-heading\">2017<\/h4><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade\" id=\"tab-d50719bfcae37bebbfb\">\n<p>O Programa PAPSummer n\u00e3o se realizar\u00e1 em 2017. Consulte o nosso website para atualiza\u00e7\u00f5es sobre o Programa PAPSummer 2018 ou\u00a0<a href=\"http:\/\/www.paps.pt\/pt-pt\/about\/contactos\/\">contacte-nos<\/a>\u00a0caso pretenda que o seu nome seja adicionado &#8216;a nossa\u00a0<i>mailing list<\/i>.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t<\/div>\n\t\t<\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1953","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/pages\/1953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/comments?post=1953"}],"version-history":[{"count":2,"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/pages\/1953\/revisions"}],"predecessor-version":[{"id":2099,"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/pages\/1953\/revisions\/2099"}],"wp:attachment":[{"href":"https:\/\/www.paps.pt\/pt-pt\/wp-json\/wp\/v2\/media?parent=1953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}